In 1986, the hip hop group Run-D.M.C. performed a cover of "Walk This Way" with Steven Tyler and Joe Perry guesting on vocals and guitars. While working on Raising Hell, Rick Rubin pulled out Toys in the Attic (an album they freestyled over) and explained who Aerosmith were. While Run and DMC had no idea who Aerosmith were at that time, Jam Master Jay suggested remaking the song.

This has got to be one of the most historic cross over collaborations of all time.